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Home / All Peptides / GLP Receptor Agonists / GLP3-R
GLP Receptor Agonists

GLP3-R

CAS # 2381089-83-2
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Lot BTCH-PE-99-334 ·10mg ·Third-party tested
99.8%
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Compound Overview

About GLP3-R

GLP3-R is a triple receptor agonist research peptide in the retatrutide class, engineered to activate GLP-1, GIP, and glucagon receptors simultaneously. It is studied in metabolic research models examining energy balance, incretin signaling, and body composition.

GLP3-R is a synthetic triple agonist research peptide modeled on the retatrutide class of investigational compounds. By engaging three distinct receptors — GLP-1, GIP, and glucagon — in a single molecule, it gives laboratories a tool for examining how combined incretin and glucagon signaling influences energy expenditure, appetite-related pathways, and glucose regulation in preclinical models.

Research Applications

  • Incretin receptor pharmacology and multi-receptor agonism studies
  • Preclinical models of metabolic regulation and energy balance
  • Comparative studies against single and dual agonist compounds
  • Receptor binding, signaling, and downstream pathway analysis

For the class background — mechanism, published evidence, and how laboratories structure comparisons — read our full research overview of retatrutide and the triple agonist class.

Handling & Storage

Supplied as a lyophilized powder. Store sealed vials in a cool, dry place away from light; refrigerate after reconstitution with bacteriostatic water and avoid repeated freeze-thaw cycles.

This compound is intended for in-vitro research and laboratory use only. Not for human consumption.

Chemical Reference

Understanding the Mechanism of GLP3-R Research Peptides

CAS #2381089-83-2
Molecular FormulaC221H342N46O68
Molecular Weight~4,731.3 g/mol
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Proof belongs on the product page.

Every batch of GLP3-R is independently tested for identity and purity, and ships with its own Certificate of Analysis — lot information included, where a researcher can actually find it.

View Testing Documentation →
PRISTINEAMINOS Certificate of Analysis
GLP3-R · Current batch results

Independently tested by an ISO/IEC 17025 accredited third-party lab. Click a batch to view the full certificate.

Selected Studies · Peer-Reviewed Literature

References

A curated list of published, peer-reviewed papers indexed in PubMed where GLP3-R's compound class has been studied. Provided for research context only — linking to the literature does not constitute endorsement of any therapeutic application.

01
Katsi V et al. (2025) · Biomolecules
Retatrutide-A Game Changer in Obesity Pharmacotherapy
PubMed · 40563436 ↗
02
Jastreboff AM et al. (2023) · N Engl J Med
Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial
PubMed · 37366315 ↗
03
Giblin K et al. (2026) · Diabetes Obes Metab
Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials
PubMed · 41090431 ↗
04
Rosenstock J et al. (2023) · Lancet
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
PubMed · 37385280 ↗
Common Questions

Frequently Asked Questions

What is GLP3-R used for in research?

GLP3-R is a triple receptor agonist research peptide in the retatrutide class, engineered to activate GLP-1, GIP, and glucagon receptors simultaneously. It is studied in metabolic research models examining energy balance, incretin signaling, and body composition. This compound is intended for in-vitro research and laboratory use only. Not for human consumption.

How is purity verified?

Every batch is independently third-party tested using HPLC purity analysis and mass spectrometry. We guarantee ≥99% purity on all our research peptides, with a full Certificate of Analysis provided for each lot.

When does my order ship?

Orders placed before 4PM Pacific Time ship same-day, Monday–Friday. You'll receive a tracking number via email once your order leaves our facility. All orders are shipped with discreet packaging.

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