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Home / All Peptides / General Health/Wellness / MOTS-C
General Health/Wellness

MOTS-C

CAS # 1627580-64-6
LATEST VERIFIED LOT
Certificate of Analysis
Lot 20260702-001 ·10mg ·Third-party tested
99.51%
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Compound Overview

About MOTS-C

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied for AMPK activation, metabolic homeostasis, and exercise-related cell signaling in preclinical research.

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16 amino acid peptide encoded within the mitochondrial genome. As one of the best characterized mitochondrial-derived peptides, it is studied for its role in AMPK pathway activation, glucose and fat metabolism, and cellular stress adaptation across in vitro and animal models.

Research Applications

  • AMPK signaling and metabolic homeostasis studies
  • Mitochondrial-nuclear communication research
  • Exercise physiology and muscle cell models
  • Cellular stress resistance and aging-related research

Handling & Storage

Supplied as a lyophilized powder. Store sealed vials in a cool, dry place away from light; refrigerate after reconstitution with bacteriostatic water and avoid repeated freeze-thaw cycles.

This compound is intended for in-vitro research and laboratory use only. Not for human consumption.

Chemical Reference

MOTS-C Structure

MOTS-C molecular structure
CAS #1627580-64-6
Molecular FormulaC101H152N28O22S2
Molecular Weight~2,174.6 g/mol
PubChem ID146675088
Documentation over decoration

Proof belongs on the product page.

Every batch of MOTS-C is independently tested for identity and purity, and ships with its own Certificate of Analysis — lot information included, where a researcher can actually find it.

View Testing Documentation →
PRISTINEAMINOS Certificate of Analysis
MOTS-C · Current batch results

Independently tested by an ISO/IEC 17025 accredited third-party lab. Click a batch to view the full certificate.

Selected Studies · Peer-Reviewed Literature

References

A curated list of published, peer-reviewed papers indexed in PubMed where MOTS-C has been studied. Provided for research context only — linking to the literature does not constitute endorsement of any therapeutic application.

01
Zheng Y et al. (2023) · Front Endocrinol (Lausanne)
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
PubMed · 36761202 ↗
02
Lee C et al. (2015) · Cell Metab
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
PubMed · 25738459 ↗
03
Yin Y et al. (2024) · Adv Sci (Weinh)
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination
PubMed · 39321430 ↗
04
Yin Y et al. (2022) · Pharmacol Res
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus
PubMed · 34798268 ↗
Common Questions

Frequently Asked Questions

What is MOTS-C used for in research?

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied for AMPK activation, metabolic homeostasis, and exercise-related cell signaling in preclinical research. This compound is intended for in-vitro research and laboratory use only. Not for human consumption.

How is purity verified?

Every batch is independently third-party tested using HPLC purity analysis and mass spectrometry. We guarantee ≥99% purity on all our research peptides, with a full Certificate of Analysis provided for each lot.

When does my order ship?

Orders placed before 4PM Pacific Time ship same-day, Monday–Friday. You'll receive a tracking number via email once your order leaves our facility. All orders are shipped with discreet packaging.

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